--------------- EVENT DETAILS ------------------- UPDATE 02/02/2025: DEADLINE HAS BEEN EXTENDED . END OF UPDATE .--------------------------------------------- AGENT CONTACT: MACKENZIE PARTNERS (212) 929-5500 OR CALL TOLL-FREE 1-800-322-2885 EMAIL: TENDEROFFER (AT) MACKENZIEPARTNERS .COM. . AT2B, INC., A DELAWARE CORPORATION AND AN INDIRECT WHOLLY OWNED SUBSIDIARY OF CYCLE GROUP HOLDINGS LIMITED, A PRIVATE LIMITED COMPANY INCORPORATED IN ENGLAND AND WALES, IS OFFERING TO PURCHASE ALL OF THE ISSUED AND OUTSTANDING SHARES OF COMMON STOCK, PAR VALUE USD 0.0001 PER SHARE, OF APPLIED THERAPEUTICS, INC., A DELAWARE CORPORATION, AT A PURCHASE PRICE OF (I) USD 0.088 PER SHARE, NET TO THE SELLER IN CASH, WITHOUT INTEREST PLUS (II) ONE NON-TRADEABLE CONTINGENT VALUE RIGHT, WHICH REPRESENTS THE CONTRACTUAL RIGHT TO RECEIVE UP TO FOUR CONTINGENT CASH PAYMENTS. . AN AGGREGATE OF USD 0.40 PER CVR PLUS AN AMOUNT EQUAL TO EACH CVR HOLDERS PRO RATA PORTION OF ANY CLOSING CASH PAYMENT UPON THE ACHIEVEMENT OF THE SPECIFIED MILESTONES AND EXISTENCE OF CLOSING CASH THAT EXCEEDS USD 500,000 BUT IS LESS THAN USD 1,500,000 AT THE EFFECTIVE TIME. IN ACCORDANCE WITH THE TERMS AND SUBJECT TO THE CONDITIONS OF A CONTINGENT VALUE RIGHTS AGREEMENT TO BE ENTERED INTO WITH A RIGHTS AGENT SELECTED BY PARENT AND REASONABLY ACCEPTABLE TO THE COMPANY, AT THE TIMES PROVIDED FOR IN THE CVR AGREEMENT, NET TO THE SELLER IN CASH, WITHOUT INTEREST AND LESS ANY APPLICABLE TAX WITHHOLDING, UPON THE TERMS AND SUBJECT TO THE CONDITIONS SET FORTH IN THE OFFER TO PURCHASE AND IN THE RELATED LETTER OF TRANSMITTAL . HOLDERS MUST OBTAIN THE OFFER TO PURCHASE, RELATED LETTER OF TRANSMITTAL, NOGD AND SCHEDULE 14D-9, DATED 29/12/ 2025, FOR COMPLETE TERMS AND CONDITIONS OF THE OFFER. . WE DID NOT RECEIVE INFORMATION THAT WOULD INDICATE THAT THIS OFFER IS SUBJECT TO IRS PLR 302. . NO DOCUMENTATION AVAILABLE . THIS CORPORATE ACTION NOTIFICATION DOES NOT CONSTITUTE AN OFFER TO SELL OR THE SOLICITATION OF AN OFFER TO BUY ANY SECURITIES BY ANYONE IN ANY JURISDICTION. IT IS NOT, AND SHOULD NOT BE CONSTRUED OR TREATED AS, INVESTMENT OR FINANCIAL ADVICE. IN PROVIDING THIS INFORMATION, EUROCLEAR BANK IS NOT ACTING AS AGENT OF THE ISSUER. BY SENDING AN INSTRUCTION TO EUROCLEAR BANK, YOU CONFIRM THAT YOU (AND ANY BENEFICIAL OWNER(S) FOR WHOM YOU ACT) COMPLY WITH THE TERMS AND CONDITIONS OF THE CORPORATE EVENT AND COMPLY WITH APPLICABLE LOCAL LAWS OR REQUIREMENTS, INCLUDING BUT NOT LIMITED TO HOLDING AND TRANSFER RESTRICTIONS. IF HOLDING AND TRANSFER RESTRICTIONS WOULD PROHIBIT YOU (AND ANY BENEFICIAL OWNER(S) FOR WHOM YOU ACT) TO HOLD THE PROCEEDS OF A CORPORATE EVENT IN YOUR ACCOUNT IN EUROCLEAR BANK, YOU (AND ANY BENEFICIAL OWNER(S) FOR WHOM YOU ACT) MUST ENSURE TO SEND AN INSTRUCTION TO ALLOW THE TRANSFER OF THESE PROCEEDS TO AN ACCOUNT OUTSIDE THE EUROCLEAR SYSTEM. .